Thisproductisfreezedried.Allwatermoleculeshavebeenremoved.
ThisantibodyisshippedwithitsantigenFREEofcharge!
Thislyophilizedproductisshippedatroomtemperature.Pleaseseeitscertificateofanalysisforfurtherstorageinstructions.
___Cells+ Anti-α1B-AdrenergicReceptor(extracellular)-ATTO-488 Antibody(#AAR-018-AG),(10µg/5x105 cells).
- IUPHARRECEPTORDATABASE|ADRENOCEPTORS
- Piascik,M.T.andPerez,D.M.(2001)J.Pharmacol.Exp.Ther.298,403.
- Perez,D.M.etal.(1993)Mol.Pharmacol.44,784.
- Minneman,K.P.(1988)Pharmacol.Rev.40,87.
- Schwinn,D.A.etal.(2004)MayoClin.Proc.79,1423.
Adrenergicreceptors(alsocalledadrenoceptors)arethereceptorsforthecatecholaminesadrenalineandnoradrenaline(calledepinephrineandnorepinephrineintheUnitedStates).Adrenalineandnoradrenalineplayimportantrolesinthecontrolofbloodpressure,myocardialcontractilerateandforce,airwayreactivity,andavarietyofmetabolicandcentralnervoussystemfunctions.
Adrenergicreceptorsaremembersofthe G-proteincoupledreceptor (GPCR)superfamilyofmembraneproteins.Theyshareacommonstructureofsevenputativetransmembranedomains,anextracellularaminoterminus,andacytoplasmiccarboxylterminus.
Adrenoceptorsaredividedintothreetypes:α1,α2 andβadrenoceptors.Eachtypeisfurtherdividedintoatleastthreesubtypes:α1A,α1B,α1D,α2A,α2B,α2C,β1,β2,β3.1,2 Theyareexpressedinnearlyallperipheraltissuesandinthecentralnervoussystem.1,2
Allα1-adrenoceptors(α1-ARs)activatephospholipasesCandA2.3 Inadditiontomobilizingintracellularcalcium,theα1-ARshavealsobeenshowntoactivatecalciuminfluxviavoltage-dependentand-independentcalciumchannels.4
α1B-Adrenoceptorpopulationsaregreatestinthespleen,kidney,cerebellum,andfetalbrain.5
α1B-Adrenoceptorcausescontractionofsmoothmusclecellsandtherebycontrolsvasculartone,bloodpressure,andacceleratesthedevelopmentofatherosclerosis.5
Anti-α1B–AdrenergicReceptor(extracellular)Antibody(#AAR-018)isahighlyspecificantibodydirectedagainstanextracellularepitopeofthehumanα1B-adrenoceptor.Theantibodycanbeusedinwesternblot,immunohistochemistry,livecellimagingandindirectflowcytometryapplications.Ithasbeendesignedtorecognizeα1B-adrenoceptorfromhuman,ratandmousesamples.
Anti-α1B-AdrenergicReceptor(extracellular)-ATTO-488Antibody(#AAR-018-AG)isdirectlylabeledwithanATTO-488fluorescentdye.ATTOdyesarecharacterizedbystrongabsorption(highextinctioncoefficient),highfluorescencequantumyield,andhighphoto-stABIlity.TheATTO-488labelisanalogoustothewellknowndyefluoresceinisothiocyanate(FITC)andcanbeusedwithfilterstypicallyusedtodetectFITC.Anti-α1B-AdrenergicReceptor(extracellular)-ATTO-488Antibody hasbeentestedindirectflowcytometryapplicationsandisspeciallysuitedtoexperimentsrequiringsimultaneouslabelingofdifferentMarkers.
___Cells+ Anti-α1B-AdrenergicReceptor(extracellular)-ATTO-488 Antibody(#AAR-018-AG),(10µg/5x105 cells).
- IUPHARRECEPTORDATABASE|ADRENOCEPTORS
- Piascik,M.T.andPerez,D.M.(2001)J.Pharmacol.Exp.Ther.298,403.
- Perez,D.M.etal.(1993)Mol.Pharmacol.44,784.
- Minneman,K.P.(1988)Pharmacol.Rev.40,87.
- Schwinn,D.A.etal.(2004)MayoClin.Proc.79,1423.